Yes, I've read all the FAQs including the Vista compatibility settings advice. It's weird. The screen flashes, but if I hold down the mouse button for a second or so then release it, it carries out the action. It does just make the game unplayable though. This is what I've tried so far, I've changed the resolution of my PC to 1280x1024 and then edited the config file to reflect the same resolution. I've set all the compatibility options all the way back to Win95. I've reinstalled, repaired the install, I've even tried to use the Nvidia control panel (I have a 8800 GTX SLI setup on my laptop) and nothing works. It is such a weird issue the screen flash starts right from the beginning of the first intro video. Somehow the mouse loses its focus and unless I hold it down, the mouse request gets ignored. Any help please?