I think I run it on a Nvidia GTX 440, so if your's is close to that it should work. Mine's not outstanding by any means (only $100), but I can run High settings with the occasional lag from a lot of units onscene or whatever. I just gotta say, I'm loving the little improvements here and there. But man, I've been getting a lot of Gas Explosions with 15+ casualties. Just now, I had one that blew up my E54 and it engulfed pretty much the entire block. The only problem though is that the construction workers fall into the holes and I can't seem to lift them out...but anyway, I should get this on Fraps next time. Pretty insane gameplay lol.